Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (JFIKI) Vol 5 No 2

Umi, Athiyah (2018) Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (JFIKI) Vol 5 No 2. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (JFIKI), 5 (2). pp. 56-106. ISSN 2406-9388

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Abstract

Background: Gastric ulcer is a disease caused by disturbances in the upper gastrointestinal tract caused by excessive secretion of acid and pepsin by the gastric mucosa. Gastric ulceration can occur due to excessive consumption of alcohol because it damages the gastric mucosal barrier and causes acute gastritis such as gastrointestinal bleeding. Bengkuang (Pachyrhizus erosus L.) contains flavonoids which is well-known to reduce stomach acid as a curative agent. Objective: To see the effect of bengkuang juice as a preventive agent on mice (Mus musculus L.) induced by gastric ulcer using alcohol. Methods: Giving bengkuang juice orally with doses of 20, 40, and 60% and sucralfate as a positive control for 12 days. After 1 hour of treatment on the 12th day, mice were given 5 g/Kg of ethanol for 24 hours. Results: The results showed that the index values of gastric ulcer in the normal group, negative control, bengkuang juice doses 20, 40, and 60%, and sucralfate were 0; 3.89; 0.56; 0.22; 1.22 and 1.11 respectively. This is supported by the histopathological depiction of the stomach of the mice which also showed improvement in the stomach of the mouse which was given bengkuang juice. Conclusion: Giving bengkuang juice can reduce the number of ulcers with an improvement in histopathological depiction of mice stomach.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Library of Congress Subject Areas > P Language and Literature > Farmasi
Library of Congress Subject Areas > P Language and Literature > Fakultas Farmasi > Farmasi
Fakultas Farmasi > Farmasi
Depositing User: Unnamed user with email repo@umsb.ac.id
Date Deposited: 06 Sep 2022 03:00
Last Modified: 06 Sep 2022 03:00
URI: http://eprints.umsb.ac.id/id/eprint/358

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