AKTIVITAS IN VITRO DAN IN VIVO ANTI HIPERGLISEMIA DARI EKSTRAK AIR SERAI (Cymbopogon citratus) YANG DIKERINGKAN DENGAN METODE SPRAY-DRYING

Maria, Dewi Puspitasari Tirtaningtyas Gunawan-Puteri and Felicia, Rustandi and Phebe, Hendra (2018) AKTIVITAS IN VITRO DAN IN VIVO ANTI HIPERGLISEMIA DARI EKSTRAK AIR SERAI (Cymbopogon citratus) YANG DIKERINGKAN DENGAN METODE SPRAY-DRYING. JURNAL FARMASI SAINS DAN KOMUNITAS, 15 (2). pp. 55-61. ISSN 1693-5683

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Abstract

Lemongrass was found to be a promising herb for anti-hyperglycemia treatment due to its activities to inhibit alpha glucosidase and alpha amylase in vitro activities and ability to improve blood glucose profile. Lemongrass potency through its anti-hyperglycemic ingredients requires evaluation of the functional stability during processing. In this study, the in vitro anti-hyperglycemic activities of spraydried aqueous extract of lemongrass were determined by its inhibitory activity against rat intestinal glucosidase enzymatic hydrolysis of sucrose. In vivo activity was observed based on its ability to prevent blood glucose elevation in oral glucose, sucrose and maltose tolerance tests (OGTT, OSTT and OMTT). The in vitro evaluation showed that aqueous extraction, which involved stirring at 70 °C for 40 min, successfully increased the glucosidase inhibitory activity of lemongrass extract, while spray drying with inlet 130 °C had no significant impact to the activity tested in vitro. Spray-dried lemongrass powder was found to be effective for lowering blood glucose level in OGTT, OSTT and OMTT. This study provides support for further development of lemongrass extracts as functional ingredients for hyperglycemia treatment.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Library of Congress Subject Areas > P Language and Literature > Farmasi
Library of Congress Subject Areas > P Language and Literature > Fakultas Farmasi > Farmasi
Fakultas Farmasi > Farmasi
Depositing User: Unnamed user with email repo@umsb.ac.id
Date Deposited: 08 Sep 2022 02:21
Last Modified: 08 Sep 2022 02:21
URI: http://eprints.umsb.ac.id/id/eprint/374

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