Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (JFIKI) Vol 7 No 2

Junaidi, Khotib (2020) Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (JFIKI) Vol 7 No 2. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia (JFIKI), 7 (2). pp. 59-113. ISSN 2406-9388

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Abstract

Background: Skin, the largest organ in human body is an important site for delivering drug or active ingredients. Some active ingredients are macromolecule with molecule size more than 500 Da hence delivering it into stratum corneum become more challenging and need penetration enhancer to traverse the stratum corneum. SPACE (Skin Penetrating and Cell Entering) are sequences of small molecule of peptide which have demonstrated their potential as enhancer in delivering macromolecule in non invasive way. SPACE is nouvelle enhancer and the study about their effects on physical characteristic and stability in topical gel formulation are limited. Objective: This research was conducted to examine the effect of SPACE toward physical characteristic and stability of Amniotic Membrane Stem Cell-Metabolite Product gel. Methods: Gel physical characteristics were measured by evaluating gel physical appearance, pH and spreading diameter measurement. The physical stability test was evaluated by observing organoleptic parameter, pH and spreading diameter measurement during 30 days of storage. Results: The result of physical stability test showed that the observed gel have transparent appearance, thick consistency and smooth texture with pH around 6.1 and spreading diameter 6.0 cm. Freeze dried AMSC-MP gel was stable during 30 days of storage. Conclusion: The addition of SPACE to gel formulation did not disturb the gel physical characteristic and stability.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Library of Congress Subject Areas > P Language and Literature > Farmasi
Library of Congress Subject Areas > P Language and Literature > Fakultas Farmasi > Farmasi
Fakultas Farmasi > Farmasi
Depositing User: Unnamed user with email repo@umsb.ac.id
Date Deposited: 06 Sep 2022 02:48
Last Modified: 06 Sep 2022 02:48
URI: http://eprints.umsb.ac.id/id/eprint/356

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