ANTI-DIARRHEAL ACTIVITY OF AQUEOUS EXTRACT OF NAGASARI FLOWERS (Mesua ferrea L.) IN BALB/c MICE INDUCED BY Escherichia coli

Putu, Monik Ananta Puspitarini and Iman, Surya Pratama and Bambang, Fajar Suryadi (2019) ANTI-DIARRHEAL ACTIVITY OF AQUEOUS EXTRACT OF NAGASARI FLOWERS (Mesua ferrea L.) IN BALB/c MICE INDUCED BY Escherichia coli. JURNAL FARMASI SAINS DAN KOMUNITAS, 16 (2). pp. 50-55. ISSN 1693-5683

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Abstract

Nagasari (Mesua ferrea L.) is empirically used for management for diarrhea in Nusa Tenggara Barat Province. However, the safety and efficacy of the nagasari have not been scientifically validated in an animal model. This study evaluated the activity of aqueous extract of the nagasari flowers in BALB/c mice induced by Escherichia coli to determine the effective dosage for anti-diarrheal effect. The aqueous extract of nagasari flowers (0,4% (w/v); 0,8% (w/v); and 1,6% (w/v)) was administered orally to 3 groups of mice, whereas negative and positive control received aquadestilate and ciprofloxacin 130 mg/kgBW respectively orally once daily for 3 days. The frequency and consistency of feces were observed then the total colony of E. coli in feces was calculated using colony counter. Aqueous extract of nagasari flowers at concentration 1,6% showed significant inhibitory activity against Escherichia coli comparable with positive controls (diarrhea index 0,425; p>0,05 and total colony of E. coli in feces 100,2; p>0,05). This study provides scientific support for the traditional use of aqueous extract of nagasari flowers for the treatment of diarrheal diseases.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Library of Congress Subject Areas > P Language and Literature > Farmasi
Library of Congress Subject Areas > P Language and Literature > Fakultas Farmasi > Farmasi
Fakultas Farmasi > Farmasi
Depositing User: Unnamed user with email repo@umsb.ac.id
Date Deposited: 08 Sep 2022 02:38
Last Modified: 08 Sep 2022 02:38
URI: http://eprints.umsb.ac.id/id/eprint/377

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