Preface for special issue on new analytical techniques and methods in drug metabolism and pharmacokinetics

Dongdong, Zhang (2018) Preface for special issue on new analytical techniques and methods in drug metabolism and pharmacokinetics. Xi'an Jiaotong University, China. pp. 1-79.

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Abstract

Analytical technologies and approaches for drug metabolism and pharmacokinetics (DMPK) research in the pharmaceutical in-dustry and academic research institutes have evolved rapidly overthe past decade. On one hand, the discovery and development of small molecule drug candidates requires earlier and better under-standing of their absorption, distribution, metabolism and excre-tion (ADME) in human as well as their interactions with metabolizing enzymes, transporters and drug targets, such as re-ceptors and DNA. On the other hand, several new drug modalities and deliver systems, such as peptide and protein therapeutics, anti- body-drug conjugates (ADC) and nano drug delivery systems, have been introduced into the drug pipeline. Their bioanalysis and ADME investigation in vitro and in vivo represent great challenges, and as such, demand suitable analytical technologies and strategies that may be totally different from those routinely used for DMPK studies of small molecules. This special issue of the Journal of Phar- maceutical Analysis focuses on analytical technologies and methods recently developed for improving the efficiency and qual-ity of ADME studies in support of traditional drug discovery pro-grams or for investigating the metabolism and disposition of new drug modalities and delivery systems.

Item Type: Article
Subjects: E History America > E151 United States (General)
Q Science > QD Chemistry
Divisions: Library of Congress Subject Areas > P Language and Literature > Farmasi
Library of Congress Subject Areas > P Language and Literature > Fakultas Farmasi > Farmasi
Fakultas Farmasi > Farmasi
Depositing User: Unnamed user with email repo@umsb.ac.id
Date Deposited: 28 Sep 2022 07:46
Last Modified: 28 Sep 2022 07:46
URI: http://eprints.umsb.ac.id/id/eprint/492

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