Haruko, Kumamoto and Taku, Yamaguchi and Kohtarou, Konno and Takeshi, Izumi (2017) Repeated fluvoxamine treatment recovers early postnatal stress-induced hypersociability-like behavior in adult rats. Nagasaki International University, Sasebo 859-3298, Japan. pp. 1-49.
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Abstract
Childhood maltreatment is associated with impaired adult brain function, particularly in the hippo- campus, and is not only a major risk factor for some psychiatric diseases but also affects early social development and social adaptation in later life. The aims of this study were to determine whether early postnatal stress affects social behavior and whether repeated fluvoxamine treatment reverses these changes. Rat pups were exposed to footshock stress during postnatal days 21e25 (at 3 weeks old: 3wFS). During the post-adolescent period (10e14 weeks postnatal), the social interaction test and Golgi-cox staining of dorsal hippocampal pyramidal neurons were performed. Following exposure to footshock stress, 3wFS rats showed an increase in social interaction time, which might be practically synonymous with hypersociability, and a decrease in spine density in the CA3 hippocampal subregion, but not in CA1. These behavioral and morphological changes were both recovered by repeated oral administration of fluvoxamine at a dose of 10 mg/kg/day for 14 days. These findings suggest that the vulnerability of the hippocampal CA3 region is closely related to social impairments induced by physical stress during the juvenile period and shed some light on therapeutic alternatives for early postnatal stress-induced emotional dysfunction. © 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Divisions: | Library of Congress Subject Areas > P Language and Literature > Farmasi Library of Congress Subject Areas > P Language and Literature > Fakultas Farmasi > Farmasi Fakultas Farmasi > Farmasi |
| Depositing User: | Unnamed user with email repo@umsb.ac.id |
| Date Deposited: | 28 Sep 2022 08:36 |
| Last Modified: | 28 Sep 2022 08:36 |
| URI: | http://eprints.umsb.ac.id/id/eprint/508 |
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